April 6, 2021


U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549-3720




Tim Buchmiller



Outset Medical, Inc.


Registration Statement on Form S-1


File No. 333-255062

Acceleration Request


Requested Date:


April 8, 2021

Requested Time:


4:00 P.M., Eastern Time

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Outset Medical, Inc. (the “Company”), hereby requests that the effective date of the Company’s Registration Statement on Form S-1, Registration Number 333-255062 (the “Registration Statement”) be accelerated so that the Company’s Registration Statement will become effective at 4:00 P.M. Eastern Time, on April 8, 2021, or as soon thereafter as practicable or at such later time as the Company or its counsel may orally request via telephone call to the staff of the Division of Corporation Finance of the U.S. Securities and Exchange Commission.

We would appreciated it if, as soon as the Registration Statement is declared effective, you would so inform Robert A. Ryan of Sidley Austin LLP at (212) 839-5931.


Very truly yours,


/s/ John L. Brottem

John L. Brottem

General Counsel

Outset Medical, Inc.




Leslie Trigg, President, Chief Executive Officer and Director


Rebecca Chambers, Chief Financial Officer


Frank F. Rahmani, Sidley Austin LLP


Robert A. Ryan, Sidley Austin LLP


Helen Theung, Sidley Austin LLP


Nathan Ajiashvili, Latham & Watkins LLP


Brian Cuneo, Latham & Watkins LLP


Salvatore Vanchieri Jr., Latham & Watkins LLP